Advanced Rat Mammary Cancers Are Growth Hormone Dependent

Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers

Both estrogen (E) and progesterone (P) are implicated in the etiology of human breast cancer. Defining their mechanisms of action, particularly in vivo, is relevant to the prevention and therapy of breast cancer. We investigated the molecular and cellular mechanisms of E and/or P-induced in vivo proliferation, in the normal rat mammary gland and in hormone-dependent rat mammary cancers which sh...

Comparison of macromolecular binding of estradiol in hormone-dependent and hormone-independent rat mammary carcinoma.

In rat mammary carcinoma, 2 types of cytoplasmic estradiol-binding sites, A and B, are present. The A sites are excluded on Sephadex G-100 chromatography, sediment at 8 S and 4 S in a low-ionic-strength sucrose gradient or at 4 S alone in a high-ionic-strength sucrose gradient, and form an insoluble complex with protamine sulfate. They have a very high affinity for estradiol (Kd ~ 1.2 X IO"10 M...

Growth hormone-releasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and -independent prostate cancers.

The antiproliferative effects of an antagonist of growth hormone-releasing hormone (GHRH) JV-1-38 were evaluated in nude mice bearing s.c. xenografts of LNCaP and MDA-PCa-2b human androgen-sensitive and DU-145 androgen-independent prostate cancers. In the androgen-sensitive models, JV-1-38 greatly potentiated the antitumor effect of androgen deprivation induced by surgical castration, but was i...

Oestrogens, Xenoestrogens and Hormone-Dependent Cancers

FOXA1 mutations in hormone-dependent cancers

The forkhead protein, FOXA1, is a critical interacting partner of the nuclear hormone receptors, oestrogen receptor-α (ER) and androgen receptor (AR), which are major drivers of the two most common cancers, namely breast and prostate cancer. Over the past few years, progress has been made in our understanding of how FOXA1 influences nuclear receptor function, with both common and distinct roles...